| # | Eastern Conference | PTS | GP | W | T | L | GS | GC | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Philadelphia Union | 66 | 34 | 20 | 6 | 8 | 57 | 35 | LWWWL |
| 2 |  FC Cincinnati | 65 | 34 | 20 | 5 | 9 | 52 | 40 | WWDWW |
| 3 |  Inter Miami | 65 | 34 | 19 | 8 | 7 | 81 | 55 | DLWWW |
| 4 |  Charlotte | 59 | 34 | 19 | 2 | 13 | 55 | 46 | WLLWW |
| 5 |  New York City FC | 56 | 34 | 17 | 5 | 12 | 50 | 44 | WLWLL |
| 6 |  Nashville SC | 54 | 34 | 16 | 6 | 12 | 58 | 45 | LLWDL |
| 7 |  Columbus Crew | 54 | 34 | 14 | 12 | 8 | 55 | 51 | LDLDW |
| 8 |  Chicago Fire | 53 | 34 | 15 | 8 | 11 | 68 | 60 | WWWDD |
| 9 |  Orlando City SC | 53 | 34 | 14 | 11 | 9 | 63 | 51 | WDDLL |
| 10 |  New York Red Bulls | 43 | 34 | 12 | 7 | 15 | 48 | 47 | LWLLL |
| 11 |  New England Revolution | 36 | 34 | 9 | 9 | 16 | 44 | 51 | DLWLD |
| 12 |  Toronto FC | 32 | 34 | 6 | 14 | 14 | 37 | 44 | DDDLW |
| 13 |  Montreal Impact | 28 | 34 | 6 | 10 | 18 | 34 | 60 | LLWDL |
| 14 |  Atlanta United FC | 28 | 34 | 5 | 13 | 16 | 38 | 63 | DLLLD |
| 15 |  DC United | 26 | 34 | 5 | 11 | 18 | 30 | 66 | DLLLD |
| # | Western Conference | PTS | GP | W | T | L | GS | GC | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1 | San Diego | 63 | 34 | 19 | 6 | 9 | 64 | 41 | LDLWW |
| 2 |  Vancouver Whitecaps | 63 | 34 | 18 | 9 | 7 | 66 | 38 | DDWWL |
| 3 |  Los Angeles FC | 60 | 34 | 17 | 9 | 8 | 65 | 40 | WWWLD |
| 4 |  Minnesota United FC | 58 | 34 | 16 | 10 | 8 | 56 | 39 | WLDWL |
| 5 | Seattle Sounders | 55 | 34 | 15 | 10 | 9 | 58 | 48 | LDWWW |
| 6 |  Austin | 47 | 34 | 13 | 8 | 13 | 37 | 45 | WLLWL |
| 7 |  FC Dallas | 44 | 34 | 11 | 11 | 12 | 52 | 55 | WDWLW |
| 8 |  Portland Timbers | 44 | 34 | 11 | 11 | 12 | 41 | 48 | LDDLL |
| 9 |  Real Salt Lake | 41 | 34 | 12 | 5 | 17 | 38 | 49 | LWWLD |
| 10 |  San Jose Earthquakes | 41 | 34 | 11 | 8 | 15 | 60 | 63 | LLWLW |
| 11 |  Colorado Rapids | 41 | 34 | 11 | 8 | 15 | 44 | 56 | WLDLD |
| 12 |  Houston Dynamo | 37 | 34 | 9 | 10 | 15 | 43 | 56 | LWLLD |
| 13 |  St. Louis City | 32 | 34 | 8 | 8 | 18 | 44 | 58 | WWLWD |
| 14 |  Los Angeles Galaxy | 30 | 34 | 7 | 9 | 18 | 46 | 66 | LWLWW |
| 15 |  Sporting Kansas City | 28 | 34 | 7 | 7 | 20 | 46 | 70 | LLLLD |
