| # | Eastern Conference | PTS | MP | W | D | L | GS | GC | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Inter Miami | 74 | 34 | 22 | 8 | 4 | 79 | 49 | WWWLL |
| 2 |  Columbus Crew | 66 | 34 | 19 | 9 | 6 | 72 | 40 | WWWLD |
| 3 |  FC Cincinnati | 59 | 34 | 18 | 5 | 11 | 58 | 48 | LWWLD |
| 4 |  Orlando City SC | 52 | 34 | 15 | 7 | 12 | 59 | 50 | WDDWL |
| 5 |  Charlotte | 51 | 34 | 14 | 9 | 11 | 46 | 37 | WWLDD |
| 6 |  New York City FC | 50 | 34 | 14 | 8 | 12 | 54 | 49 | LLWDL |
| 7 |  New York Red Bulls | 47 | 34 | 11 | 14 | 9 | 55 | 50 | WDWWL |
| 8 |  Montreal Impact | 43 | 34 | 11 | 10 | 13 | 48 | 64 | WWWLW |
| 9 |  Atlanta United FC | 40 | 34 | 10 | 10 | 14 | 46 | 49 | WLWWL |
| 10 | DC United | 40 | 34 | 10 | 10 | 14 | 52 | 70 | LDWWL |
| 11 |  Toronto FC | 37 | 34 | 11 | 4 | 19 | 40 | 61 | LLDLL |
| 12 |  Philadelphia Union | 37 | 34 | 9 | 10 | 15 | 62 | 55 | WDLLL |
| 13 |  Nashville SC | 36 | 34 | 9 | 9 | 16 | 38 | 54 | DLLLW |
| 14 |  New England Revolution | 31 | 34 | 9 | 4 | 21 | 37 | 74 | WLLLL |
| 15 |  Chicago Fire | 30 | 34 | 7 | 9 | 18 | 40 | 62 | LLDLL |
| # | Western Conference | PTS | MP | W | D | L | GS | GC | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Los Angeles FC | 64 | 34 | 19 | 7 | 8 | 63 | 43 | WWLWL |
| 2 |  Los Angeles Galaxy | 64 | 34 | 19 | 7 | 8 | 69 | 50 | WWWWW |
| 3 |  Real Salt Lake | 59 | 34 | 16 | 11 | 7 | 65 | 48 | DWWDD |
| 4 |  Seattle Sounders | 57 | 34 | 16 | 9 | 9 | 51 | 35 | DDDWL |
| 5 |  Houston Dynamo | 54 | 34 | 15 | 9 | 10 | 47 | 39 | WLWDD |
| 6 |  Minnesota United FC | 52 | 34 | 15 | 7 | 12 | 58 | 49 | WWDDL |
| 7 |  Colorado Rapids | 50 | 34 | 15 | 5 | 14 | 61 | 60 | LLLLL |
| 8 |  Vancouver Whitecaps | 47 | 34 | 13 | 8 | 13 | 52 | 49 | LWLWL |
| 9 | Portland Timbers | 47 | 34 | 12 | 11 | 11 | 65 | 56 | DLDDL |
| 10 |  Austin | 42 | 34 | 11 | 9 | 14 | 39 | 48 | LDWLW |
| 11 |  FC Dallas | 41 | 34 | 11 | 8 | 15 | 54 | 56 | WLLDW |
| 12 |  St. Louis City | 37 | 34 | 8 | 13 | 13 | 50 | 63 | WWLWL |
| 13 |  Sporting Kansas City | 31 | 34 | 8 | 7 | 19 | 51 | 66 | WLLLL |
| 14 |  San Jose Earthquakes | 21 | 34 | 6 | 3 | 25 | 41 | 78 | LLWLL |
