| # | Conferencia Este | PTS | PJ | G | E | P | GF | GC | Forma |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Louisville City | 76 | 34 | 24 | 4 | 6 | 86 | 43 | GEGGP |
| 2 |  Charleston Battery | 64 | 34 | 18 | 10 | 6 | 68 | 35 | EGGGP |
| 3 |  Detroit City | 56 | 34 | 15 | 11 | 8 | 46 | 32 | EEGGE |
| 4 |  Indy Eleven | 51 | 34 | 14 | 9 | 11 | 49 | 50 | GEGPP |
| 5 |  Rhode Island | 51 | 34 | 12 | 15 | 7 | 56 | 41 | GGGGP |
| 6 |  Tampa Bay Rowdies | 50 | 34 | 14 | 8 | 12 | 55 | 46 | PEGEP |
| 7 |  Pittsburgh Riverhounds | 48 | 34 | 12 | 12 | 10 | 41 | 28 | GGGGP |
| 8 |  North Carolina | 48 | 34 | 13 | 9 | 12 | 54 | 43 | GPGGP |
| 9 |  Birmingham Legion | 45 | 34 | 13 | 6 | 15 | 44 | 51 | EPPPG |
| 10 |  Hartford Athletic | 44 | 34 | 12 | 8 | 14 | 39 | 52 | PGGEP |
| 11 |  Loudoun United | 42 | 34 | 11 | 9 | 14 | 44 | 39 | GPEPP |
| 12 |  Miami FC | 11 | 34 | 3 | 2 | 29 | 26 | 89 | PPPPP |
| # | Conferencia Oeste | PTS | PJ | G | E | P | GF | GC | Forma |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  New Mexico United | 59 | 34 | 18 | 5 | 11 | 46 | 44 | EEPGP |
| 2 |  Colorado Springs | 52 | 34 | 15 | 7 | 12 | 48 | 40 | GGGGG |
| 3 | Memphis 901 | 51 | 34 | 14 | 9 | 11 | 52 | 41 | EEGGP |
| 4 |  Las Vegas Lights | 50 | 34 | 13 | 11 | 10 | 49 | 46 | PPEGP |
| 5 |  Sacramento Republic | 49 | 34 | 13 | 10 | 11 | 46 | 34 | EEPPE |
| 6 |  Orange County SC | 46 | 34 | 13 | 7 | 14 | 38 | 45 | GEGGP |
| 7 |  Oakland Roots | 44 | 34 | 13 | 5 | 16 | 37 | 57 | EPGPP |
| 8 |  Phoenix Rising | 42 | 34 | 11 | 9 | 14 | 33 | 39 | GGPPP |
| 9 |  San Antonio | 39 | 34 | 10 | 9 | 15 | 36 | 49 | GEGEP |
| 10 | Tulsa Roughnecks | 38 | 34 | 9 | 11 | 14 | 33 | 48 | PPEPG |
| 11 |  Monterey Bay | 34 | 34 | 8 | 10 | 16 | 29 | 44 | PGEPP |
| 12 |  El Paso Locomotive | 32 | 34 | 8 | 8 | 18 | 27 | 46 | GEPGP |
