| # | Eastern Conference | PTS | MP | W | D | L | GS | GC | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh Riverhounds | 67 | 34 | 19 | 10 | 5 | 50 | 29 | WWWDL |
| 2 |  Tampa Bay Rowdies | 63 | 34 | 19 | 6 | 9 | 60 | 39 | WWLWL |
| 3 |  Charleston Battery | 59 | 34 | 17 | 8 | 9 | 47 | 43 | WWWWD |
| 4 |  Memphis 901 | 52 | 34 | 14 | 10 | 10 | 59 | 53 | WLWLD |
| 5 |  Louisville City | 50 | 34 | 14 | 8 | 12 | 41 | 44 | DLDWL |
| 6 |  Indy Eleven | 49 | 34 | 13 | 10 | 11 | 46 | 38 | LWWDL |
| 7 |  Birmingham Legion | 46 | 34 | 14 | 4 | 16 | 44 | 53 | WWLWL |
| 8 |  Detroit City | 41 | 34 | 11 | 8 | 15 | 30 | 39 | LWDWL |
| 9 |  Miami FC | 41 | 34 | 11 | 8 | 15 | 43 | 44 | WWWWL |
| 10 |  Tulsa Roughnecks | 39 | 34 | 10 | 9 | 15 | 43 | 55 | WLLLW |
| 11 |  Loudoun United | 25 | 34 | 7 | 4 | 23 | 36 | 61 | DLLLL |
| 12 |  Hartford Athletic | 18 | 34 | 4 | 6 | 24 | 40 | 79 | LLLDL |
| # | Western Conference | PTS | MP | W | D | L | GS | GC | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Sacramento Republic | 64 | 34 | 18 | 10 | 6 | 51 | 26 | WWWWL |
| 2 |  Orange County SC | 57 | 34 | 17 | 6 | 11 | 46 | 39 | WWWWL |
| 3 |  San Diego Loyal | 57 | 34 | 16 | 9 | 9 | 61 | 43 | WDWWL |
| 4 |  San Antonio | 56 | 34 | 14 | 14 | 6 | 63 | 38 | DLDWL |
| 5 |  Colorado Springs | 53 | 34 | 16 | 5 | 13 | 49 | 42 | WDWWL |
| 6 |  Phoenix Rising | 48 | 34 | 12 | 12 | 10 | 54 | 41 | LWWWD |
| 7 |  El Paso Locomotive | 47 | 34 | 13 | 8 | 13 | 41 | 51 | WDLWL |
| 8 |  New Mexico United | 46 | 34 | 13 | 7 | 14 | 51 | 49 | LWWWL |
| 9 | Rio Grande Valley | 43 | 34 | 10 | 13 | 11 | 43 | 48 | WWDLW |
| 10 |  Oakland Roots | 42 | 34 | 11 | 9 | 14 | 45 | 48 | DDLLL |
| 11 |  Monterey Bay | 41 | 34 | 11 | 8 | 15 | 42 | 53 | LDLLL |
| 12 |  Las Vegas Lights | 19 | 34 | 3 | 10 | 21 | 36 | 66 | LDLLL |
